QSAR and Anti-Depressant Studies of Some Novel Phenothiazine Derivatives

Design, Synthesis and Anti-Depressant Activity of Some Novel Coumarin Derivatives

The present research work deals with the synthesis, characterization and to evaluate the synthesized compound for antidepressant activity of a series of coumarin derivatives. Basic coumarin is prepared by Perkin reaction, which further reacted with aryl thiourea by cyclization reaction leads to produce 3-(2-(phenylaminothiazol-4-yl)-2H-chromen-2-one. Totally twelve compounds, were synthesized b...

QSAR Studies of Some Synthetic Structurally Related Androstene Derivatives as Anti-Inflammatory Agents

The use of steroids in the acute and emergency conditions of inflammation is well established. Most of the time they are given chronically to the patients with arthritis. The present study focuses on developing substantial quantitative structure activity relationship models of certain steroidal derivatives reported to be as anti-inflammatory agents. The QSAR models of androstene derivatives wer...

QSAR modeling of antimicrobial activity with some novel 1,2,4 triazole derivatives, comparison with experimental study

Our study performed upon an extended series of 28 compounds of 1,2,4-triazole derivatives that demonstrate substantial in vitro antimicrobial activities by serial plate dilution method, using quantitative structure-activity relationship (QSAR) methods that imply analysis of correlations and multiple linear regression (MLR); a significant collection of molecular descriptors was used e.g., Edge a...

Synthesis and Biological Studies of Some New Chalcone and 1,4 -Dihydropyridine Derivatives Containing Phenothiazine Moiety

QSAR Studies of Some Novel Triazines Inhibiting Dihydrofolate Reductase

In this paper the Multi-linear regression analysis has been applied for QSAR study. The relationship has been worked out between the Log 1/C values of a series of compounds and certain quantum chemical and energy descriptors. The QSAR studies of Triazines inhibiting dihydrofolate reductase based on quantum chemical and energy descriptors shows that among all the 28 QSAR models PA51 to PA 78, th...